UTILITY OF PLATELET INDICES IN THROMBOCYTOPENIA

Objectives: The objectives of the study were to know role and utility platelet indices (MPV PDW) in differentiating etiology thrombocytopenia. Methods: This was a prospective retrospective 400 cases thrombocytopenia 100 controls conducted over period 17 months from September 2020 February 2022 at tertiary care hospital, Ahmedabad, Gujarat, India. All patients meeting inclusion criteria included study. Exclusion radiation/chemotherapy, antiplatelet drugs induced thrombocytopenia, etc. EDTA blood samples collected further processed with Sysmex KX-21 automated hematology analyzer. Platelet count, mean volume (MPV), distribution width (PDW) noted data statistically analyzed between groups using t-tests. Results: Out cases, 304 belong Group A (increased destruction platelets) remaining 96 B (decreased production platelets). Among A, causes classified into immune thrombocytopenic purpura others. Various infections resulting majority among other A. comprised megaloblastic anemia as leading cause responsible for MPV PDW values high hyperdestructive compared found significant various groups. Conclusion: along count can be used an adjunct laboratory tool early screening underlying which helps clinicians targeted therapies clinical management.